WHAT IS MSI CENTER TRIAL
Trial participants who were treated with pembrolizumab also had fewer adverse events than those in the chemotherapy group. Pembrolizumab led to significantly longer progression-free survival. In a clinical trial, researchers compared pembrolizumab to chemotherapy as a first-line therapy for MSI-high metastatic colon cancer. That means you don’t have to try chemotherapy first. It’s a first-line immunotherapy for metastatic MSI-high colon cancer. This drug can only be used in combination with nivolumab, not by itself. In 2017, the Food and Drug Administration (FDA) granted accelerated approval to nivolumab (Opdivo).Ī year later, the agency granted accelerated approval to ipilimumab (Yervoy). Two of these drugs can only be used when cancer has progressed after treatment with certain chemotherapy drugs. They’re all given through intravenous infusions. Three immune checkpoint inhibitors are approved to treat MSI-high metastatic colon cancer. It’s a way of strengthening your own immune system to fight cancer. Immunotherapy is a promising treatment choice for many types of cancer. It can be used alone or in combination with other treatments.Ĭhemotherapy drugs used to treat colon cancer include:
Regional and systemic chemotherapy can help shrink tumors and prevent cancer from spreading. In the early stages of colon cancer, surgery may be the only treatment you need.Ĭancer that has spread to other organs or tissues can sometimes be surgically removed as well. In a procedure called segmental colectomy, the surgeon removes part of the colon, then attaches the ends together.
Surgery can remove many tumors in the colon. Here are some treatment options for colon cancer: Surgery MSI status can play an important role in forming a treatment plan. Treatment for colon cancer depends on several factors, such as the stage and location of the tumors.
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